An essential vesicular-trafficking phospholipase mediates neutral lipid synthesis and contributes to hemozoin formation in Plasmodium falciparum

An essential vesicular-trafficking phospholipase mediates neutral lipid synthesis and contributes to hemozoin formation in Plasmodium falciparum

Abstract Background Plasmodium falciparum is the pathogen responsible for the most devastating form of human malaria. As it replicates asexually in the erythrocytes of its human host, the parasite feeds on haemoglobin uptaken from these cells. Heme, a toxic by-product of haemoglobin utilization by t...

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Bibliographic Details
Main Authors: Mohd Asad, Yoshiki Yamaryo-Botté, Mohammad E. Hossain, Vandana Thakur, Shaifali Jain, Gaurav Datta, Cyrille Y. Botté, Asif Mohmmed
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Biology
Subjects:
Phospholipid metabolism
Phospholipase
Neutral lipids
Malaria
Host-haemoglobin
Hemozoin
Online Access:https://doi.org/10.1186/s12915-021-01042-z

Internet

https://doi.org/10.1186/s12915-021-01042-z

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