Nerve growth factor/p38 signaling increases intraepidermal nerve fiber densities in painful neuropathy of type 2 diabetes

Nerve growth factor/p38 signaling increases intraepidermal nerve fiber densities in painful neuropathy of type 2 diabetes

Painful diabetic neuropathy (PDN) is a common, yet devastating complication of type 2 diabetes. At this time, there is no objective test for diagnosing PDN. In the current study, we measured the peptidergic intraepidermal nerve fiber densities (IENFD) from hind paws of the db/db mouse, an animal mod...

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Bibliographic Details
Main Authors: Hsinlin T. Cheng, Jacqueline R. Dauch, John M. Hayes, Brandon M. Yanik, Eva L. Feldman
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Neurobiology of Disease
Subjects:
Diabetic pain
Intraepidermal nerve fibers
Type 2 diabetes
Nerve growth factor
Peptidergic nerve fibers
Mechanical allodynia
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611100266X

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http://www.sciencedirect.com/science/article/pii/S096999611100266X

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