Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway

Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway

Hydralazine is an FDA approved drug for the treatment of hypertension. Here, Dehghan et al. report that hydralazine triggers the cellular oxidative stress response by activating NRF2/SKN-1 signaling and extends C. elegans healthy lifespan, suggesting hydralazine may have potential to treat age-assoc...

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Bibliographic Details
Main Authors: Esmaeil Dehghan, Yiqiang Zhang, Bahar Saremi, Sivaramakrishna Yadavali, Amirmansoor Hakimi, Maryam Dehghani, Mohammad Goodarzi, Xiaoqin Tu, Scott Robertson, Rueyling Lin, Asish Chudhuri, Hamid Mirzaei
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02394-3

Internet

https://doi.org/10.1038/s41467-017-02394-3

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