Brucella spp. Omp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-β Production

Brucella spp. Omp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-β Production

Type I interferons (IFN), a family of cytokines widely expressed in various tissues, play important roles in anti-infection immunity. Nevertheless, it is not known whether Brucella spp. could interfere with IFN-I production induced by other pathogens. This study investigated the regulatory roles of...

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Bibliographic Details
Main Authors: Ruizhen Li, Wenli Liu, Xiangrui Yin, Fangfang Zheng, Zhenyu Wang, Xingchen Wu, Xiaohua Zhang, Qian Du, Yong Huang, Dewen Tong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Microbiology
Subjects:
Brucella spp.
Omp25
macrophage
cyclic guanosine monophosphate–adenosine monophosphate synthase
interferon β
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.702881/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.702881/full

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