Embryonic demise caused by targeted disruption of a cysteine protease Dub-2.

BACKGROUND: A plethora of biological metabolisms are regulated by the mechanisms of ubiquitination, wherein this process is balanced with the action of deubiquitination system. Dub-2 is an IL-2-inducible, immediate-early gene that encodes a deubiquitinating enzyme with growth regulatory activity. DU...

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Bibliographic Details
Main Authors: Kwang-Hyun Baek, Heyjin Lee, Sunmee Yang, Soo-Bin Lim, Wonwoo Lee, Jeoung Eun Lee, Jung-Jin Lim, Kisun Jun, Dong-Ryul Lee, Young Chung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3440420?pdf=render