Expanding the Scope of the Cleavable <i>N</i>-(Methoxy)oxazolidine Linker for the Synthesis of Oligonucleotide Conjugates
Oligonucleotides modified by a 2′-deoxy-2′-(<i>N</i>-methoxyamino) ribonucleotide react readily with aldehydes in slightly acidic conditions to yield the corresponding <i>N</i>-(methoxy)oxazolidine-linked oligonucleotide-conjugates. The reaction is reversible and dynamic in s...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/2/490 |