B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota

B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota

B-1a cells play an important role in mediating tissue homeostasis and protecting against infections. They are the main producers of ‘natural’ IgM, spontaneously secreted serum antibodies predominately reactive to self antigens, like phosphatidylcholine (PtC), or antigens expressed by the intestinal...

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Bibliographic Details
Main Authors: Lieselotte SM Kreuk, Meghan A Koch, Leianna C Slayden, Nicholas A Lind, Sophia Chu, Hannah P Savage, Aaron B Kantor, Nicole Baumgarth, Gregory M Barton
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
B cells
microbiota
Toll-like receptors
antibodies
Online Access:https://elifesciences.org/articles/47015

Internet

https://elifesciences.org/articles/47015

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