The Mammalian Response to Virus Infection Is Independent of Small RNA Silencing

A successful cellular response to virus infection is essential for evolutionary survival. In plants, arthropods, and nematodes, cellular antiviral defenses rely on RNAi. Interestingly, the mammalian response to virus is predominantly orchestrated through interferon (IFN)-mediated induction of antivi...

Full description

Bibliographic Details
Main Authors: Simone Backes, Ryan A. Langlois, Sonja Schmid, Andrew Varble, Jaehee V. Shim, David Sachs, Benjamin R. tenOever
Format: Article
Language:English
Published: Elsevier 2014-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471400432X