A small organic compound enhances the religation reaction of human topoisomerase I and identifies crucial elements for the religation mechanism

A small organic compound enhances the religation reaction of human topoisomerase I and identifies crucial elements for the religation mechanism

The different steps of the human Top1 (topoisomerase I) catalytic cycle have been analysed in the presence of a pentacyclic-diquinoid synthetic compound. The experiments indicate that it efficiently inhibits the cleavage step of the enzyme reaction, fitting well into the catalytic site. Surprisingly...

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Bibliographic Details
Main Authors: Barbara Arnò, Andrea Coletta, Cinzia Tesauro, Laura Zuccaro, Paola Fiorani, Sara Lentini, Pierluca Galloni, Valeria Conte, Barbara Floris, Alessandro Desideri
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2013-03-01
Series:Bioscience Reports
Subjects:
camptothecin
molecular docking
religation rate
topoisomerase I
Online Access:http://www.bioscirep.org/bsr/033/e025/bsr033e025.htm

Internet

http://www.bioscirep.org/bsr/033/e025/bsr033e025.htm

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