A DISINTEGRIN AND METALLOPROTEASE 17 IN THE CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEMS

A DISINTEGRIN AND METALLOPROTEASE 17 IN THE CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEMS

ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. It is somatically expressed in mammalian organisms and its proteolytic action influences several physiological and pathological proce...

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Main Authors: Jiaxi Xu, Snigdha Mukerjee, Cristiane R. A. Silva-Alves, Alynne Carvalho-Galvão, Josiane Campos Cruz, Camille M Balarini, Valdir Andrade Braga, Eric Lazartigues, Maria do Socorro França-Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Physiology
Subjects:
Atherosclerosis
Hypertension
EGFR
TNFα
shedding
ACE2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00469/full
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spelling doaj-7f897f7b84cc4835a0b81f6b50df4c1e2020-11-24T23:38:47ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2016-10-01710.3389/fphys.2016.00469227270A DISINTEGRIN AND METALLOPROTEASE 17 IN THE CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEMSJiaxi Xu0Snigdha Mukerjee1Cristiane R. A. Silva-Alves2Alynne Carvalho-Galvão3Josiane Campos Cruz4Camille M Balarini5Valdir Andrade Braga6Eric Lazartigues7Maria do Socorro França-Silva8Louisiana State University Health Sciences CenterLouisiana State University Health Sciences CenterUniversidade Federal da ParaíbaUniversidade Federal da ParaíbaUniversidade Federal da ParaíbaUniversidade Federal da ParaíbaUniversidade Federal da ParaíbaLouisiana State University Health Sciences CenterUniversidade Federal da ParaíbaADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. It is somatically expressed in mammalian organisms and its proteolytic action influences several physiological and pathological processes. This review focuses on the structure of ADAM17, its signaling in the cardiovascular system and its participation in certain disorders involving the heart, blood vessels and neural regulation of autonomic and cardiovascular modulation.http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00469/fullAtherosclerosisHypertensionEGFRTNFαsheddingACE2
collection DOAJ
language English
format Article
sources DOAJ
author Jiaxi Xu
Snigdha Mukerjee
Cristiane R. A. Silva-Alves
Alynne Carvalho-Galvão
Josiane Campos Cruz
Camille M Balarini
Valdir Andrade Braga
Eric Lazartigues
Maria do Socorro França-Silva
spellingShingle Jiaxi Xu
Snigdha Mukerjee
Cristiane R. A. Silva-Alves
Alynne Carvalho-Galvão
Josiane Campos Cruz
Camille M Balarini
Valdir Andrade Braga
Eric Lazartigues
Maria do Socorro França-Silva
A DISINTEGRIN AND METALLOPROTEASE 17 IN THE CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEMS
Frontiers in Physiology
Atherosclerosis
Hypertension
EGFR
TNFα
shedding
ACE2
author_facet Jiaxi Xu
Snigdha Mukerjee
Cristiane R. A. Silva-Alves
Alynne Carvalho-Galvão
Josiane Campos Cruz
Camille M Balarini
Valdir Andrade Braga
Eric Lazartigues
Maria do Socorro França-Silva
author_sort Jiaxi Xu
title A DISINTEGRIN AND METALLOPROTEASE 17 IN THE CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEMS
title_short A DISINTEGRIN AND METALLOPROTEASE 17 IN THE CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEMS
title_full A DISINTEGRIN AND METALLOPROTEASE 17 IN THE CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEMS
title_fullStr A DISINTEGRIN AND METALLOPROTEASE 17 IN THE CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEMS
title_full_unstemmed A DISINTEGRIN AND METALLOPROTEASE 17 IN THE CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEMS
title_sort disintegrin and metalloprotease 17 in the cardiovascular and central nervous systems
publisher Frontiers Media S.A.
series Frontiers in Physiology
issn 1664-042X
publishDate 2016-10-01
description ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. It is somatically expressed in mammalian organisms and its proteolytic action influences several physiological and pathological processes. This review focuses on the structure of ADAM17, its signaling in the cardiovascular system and its participation in certain disorders involving the heart, blood vessels and neural regulation of autonomic and cardiovascular modulation.
topic Atherosclerosis
Hypertension
EGFR
TNFα
shedding
ACE2
url http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00469/full
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