A DISINTEGRIN AND METALLOPROTEASE 17 IN THE CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEMS

A DISINTEGRIN AND METALLOPROTEASE 17 IN THE CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEMS

ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. It is somatically expressed in mammalian organisms and its proteolytic action influences several physiological and pathological proce...

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Bibliographic Details
Main Authors: Jiaxi Xu, Snigdha Mukerjee, Cristiane R. A. Silva-Alves, Alynne Carvalho-Galvão, Josiane Campos Cruz, Camille M Balarini, Valdir Andrade Braga, Eric Lazartigues, Maria do Socorro França-Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Physiology
Subjects:
Atherosclerosis
Hypertension
EGFR
TNFα
shedding
ACE2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00469/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00469/full

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