Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion.

Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion.

Primary microcephaly (MCPH) is a neurodevelopmental disorder characterized by global reduction in cerebral cortical volume. The microcephalic brain has a volume comparable to that of early hominids, raising the possibility that some MCPH genes may have been evolutionary targets in the expansion of t...

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Bibliographic Details
Main Authors: Natalay Kouprina, Adam Pavlicek, Ganeshwaran H Mochida, Gregory Solomon, William Gersch, Young-Ho Yoon, Randall Collura, Maryellen Ruvolo, J Carl Barrett, C Geoffrey Woods, Christopher A Walsh, Jerzy Jurka, Vladimir Larionov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2004-05-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC374243?pdf=render

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http://europepmc.org/articles/PMC374243?pdf=render

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