Development of a replication-competent lentivirus assay for dendritic cell-targeting lentiviral vectors

Development of a replication-competent lentivirus assay for dendritic cell-targeting lentiviral vectors

It is a current regulatory requirement to demonstrate absence of detectable replication-competent lentivirus (RCL) in lentiviral vector products prior to use in clinical trials. Immune Design previously described an HIV-1-based integration-deficient lentiviral vector for use in cancer immunotherapy...

Full description

Bibliographic Details
Main Authors: Daniel C Farley, Laura McCloskey, Barbara A Thorne, Semih U Tareen, Christopher J Nicolai, David J Campbell, Richard Bannister, Hannah J Stewart, Laura JE Pearson, Bentley J Moyer, Scott H Robbins, Leah Zielinski, Tae Kim, Pippa A Radcliffe, Kyriacos A Mitrophanous, Wayne R Gombotz, James E Miskin, Brenna Kelley-Clarke
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050116300298

Internet

http://www.sciencedirect.com/science/article/pii/S2329050116300298

Similar Items