GPR68: An Emerging Drug Target in Cancer

GPR68: An Emerging Drug Target in Cancer

GPR68 (or ovarian cancer G protein-coupled receptor 1, OGR1) is a proton-sensing G-protein-coupled receptor (GPCR) that responds to extracellular acidity and regulates a variety of cellular functions. Acidosis is considered a defining hallmark of the tumor microenvironment (TME). GPR68 expression is...

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Bibliographic Details
Main Authors: Shu Z. Wiley, Krishna Sriram, Cristina Salmerón, Paul A. Insel
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
acidosis
GPR68
proton-sensing GPCRs
RNA-seq
tumor microenvironment
Online Access:https://www.mdpi.com/1422-0067/20/3/559

Internet

https://www.mdpi.com/1422-0067/20/3/559

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