Reduced current density, partially rescued by mexiletine, and depolarizing shift in activation of SCN5A W374G channels as a cause of severe form of Brugada syndrome

Reduced current density, partially rescued by mexiletine, and depolarizing shift in activation of SCN5A W374G channels as a cause of severe form of Brugada syndrome

Abstract Background SCN5A‐related Brugada syndrome (BrS) can be caused by multiple mechanisms including trafficking defects and altered channel gating properties. Most SCN5A mutations at pore region cause trafficking defects, and some of them can be rescued by mexiletine (MEX). Objective We recently...

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Bibliographic Details
Main Authors: Tadashi Nakajima, Tommy Dharmawan, Reika Kawabata‐Iwakawa, Shuntaro Tamura, Hiroshi Hasegawa, Takashi Kobari, Masaki Ota, Shoichi Tange, Masahiko Nishiyama, Yoshiaki Kaneko, Masahiko Kurabayashi
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Annals of Noninvasive Electrocardiology
Subjects:
Brugada syndrome
mexiletine
rescue
SCN5A
trafficking defect
Online Access:https://doi.org/10.1111/anec.12828

Internet

https://doi.org/10.1111/anec.12828

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