In vitro model of neurotoxicity of Aβ 1–42 and neuroprotection by a pentapeptide: irreversible events during the first hour

In vitro model of neurotoxicity of Aβ 1–42 and neuroprotection by a pentapeptide: irreversible events during the first hour

The cell biology of Alzheimer's disease (AD) is characterized mainly by the neurodegeneration caused by the β-amyloid (Aβ) peptides and by the formation of neurofibrillary tangles. The initial events of neurodegeneration in the brain tissue include synaptic dysfunction and axonopathy. Aβ-induce...

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Bibliographic Details
Main Authors: Zsolt Datki, Rita Papp, Dénes Zádori, Katalin Soós, Lívia Fülöp, Anna Juhász, Gábor Laskay, Csaba Hetényi, Erzsébet Mihalik, Márta Zarándi, Botond Penke
Format: Article
Language:English
Published: Elsevier 2004-12-01
Series:Neurobiology of Disease
Subjects:
β-Amyloid
Neurite degeneration
Neuroblastoma cells
Aggregation
Neuroprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104001883

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http://www.sciencedirect.com/science/article/pii/S0969996104001883

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