HMG-CoA reductase is not the site of the primary defect in phytosterolemia

HMG-CoA reductase is not the site of the primary defect in phytosterolemia

Phytosterolemia is an autosomal recessive disorder characterized by the excessive absorption, reduced excretion, and consequent high tissue and plasma levels of plant sterols, by the presence of tendon xanthomas, and by premature atherosclerosis. Low HMG-CoA reductase (HRase) activity and mass have...

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Bibliographic Details
Main Authors: G.M.B. Berger, R.J. Pegoraro, S.B. Patel, P. Naidu, L. Rom, H. Hidaka, A.D. Marais, A. Jadhav, R.P. Naoumova, G.R. Thompson
Format: Article
Language:English
Published: Elsevier 1998-05-01
Series:Journal of Lipid Research
Subjects:
sitosterolemia
mevalonic acid
cholestyramine
family linkage studies
HRase gene
cholesterol synthesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520338736

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http://www.sciencedirect.com/science/article/pii/S0022227520338736

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