Immobilization of Cofactor Self-Sufficient Recombinant Escherichia coli for Enantioselective Biosynthesis of (R)-1-Phenyl-1,2-Ethanediol

Immobilization of Cofactor Self-Sufficient Recombinant Escherichia coli for Enantioselective Biosynthesis of (R)-1-Phenyl-1,2-Ethanediol

(R)-1-phenyl-1,2-ethanediol is an important synthon for the preparation of β-adrenergic blocking agents. This study identified a (2R,3R)-butanediol dehydrogenase (KgBDH) from Kurthia gibsonii SC0312, which showed high enantioselectivity for production of (R)-1-phenyl-1,2-ethanediol by reduction of 2...

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Bibliographic Details
Main Authors: Fei Peng, Hui-Hui Su, Xiao-Yang Ou, Zi-Fu Ni, Min-Hua Zong, Wen-Yong Lou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
(R)-1-phenyl-1
2-ethanediol
2-hydroxyacetophenone
(2R
3R)-butanediol dehydrogenase
asymmetric reduction
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00017/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00017/full

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