Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome

Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome

Dysregulation of insulin signaling pathway with reduced downstream neuronal survival and plasticity mechanisms is a fundamental abnormality observed in Alzheimer's disease (AD) brain. This phenomenon, known as brain insulin resistance, is associated with poor cognitive performance and is driven...

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Bibliographic Details
Main Authors: Antonella Tramutola, Chiara Lanzillotta, Fabio Di Domenico, Elizabeth Head, D. Allan Butterfield, Marzia Perluigi, Eugenio Barone
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Down syndrome
Insulin
Metabolism
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120300474

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http://www.sciencedirect.com/science/article/pii/S0969996120300474

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