On the impact of relatedness on SNP association analysis

On the impact of relatedness on SNP association analysis

Abstract Background When testing for SNP (single nucleotide polymorphism) associations in related individuals, observations are not independent. Simple linear regression assuming independent normally distributed residuals results in an increased type I error and the power of the test is also affecte...

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Bibliographic Details
Main Authors: Arnd Gross, Anke Tönjes, Markus Scholz
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Genetics
Subjects:
Heritability
Linear regression
Relatedness
SNP association analysis
Online Access:http://link.springer.com/article/10.1186/s12863-017-0571-x

Internet

http://link.springer.com/article/10.1186/s12863-017-0571-x

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