Profiles of 5α-Reduced Androgens in Humans and Eels: 5α-Dihydrotestosterone and 11-Ketodihydrotestosterone Are Active Androgens Produced in Eel Gonads

Profiles of 5α-Reduced Androgens in Humans and Eels: 5α-Dihydrotestosterone and 11-Ketodihydrotestosterone Are Active Androgens Produced in Eel Gonads

Although 11-ketotestosterone (11KT) and testosterone (T) are major androgens in both teleosts and humans, their 5α-reduced derivatives produced by steroid 5α-reductase (SRD5A/srd5a), i.e., 11-ketodihydrotestosterone (11KDHT) and 5α-dihydrotestosterone (DHT), remains poorly characterized, especially...

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Bibliographic Details
Main Authors: Takashi Yazawa, Hiroyuki Inaba, Yoshitaka Imamichi, Toshio Sekiguchi, Junsuke Uwada, Mohammad Sayful Islam, Makoto Orisaka, Daisuke Mikami, Takanori Ida, Takahiro Sato, Yoshimichi Miyashiro, Satoru Takahashi, Md. Rafiqul Islam Khan, Nobuo Suzuki, Akihiro Umezawa, Takeshi Kitano
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Endocrinology
Subjects:
DHT
11KDHT
androgen receptor
5α-reductase
testosterone
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.657360/full

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https://www.frontiersin.org/articles/10.3389/fendo.2021.657360/full

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