Hippocampal Transcriptomic Profiles: Subfield Vulnerability to Age and Cognitive Impairment

Hippocampal Transcriptomic Profiles: Subfield Vulnerability to Age and Cognitive Impairment

The current study employed next-generation RNA sequencing to examine gene expression differences related to brain aging, cognitive decline, and hippocampal subfields. Young and aged rats were trained on a spatial episodic memory task. Hippocampal regions CA1, CA3, and the dentate gyrus were isolated...

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Bibliographic Details
Main Authors: Lara Ianov, Matt De Both, Monica K. Chawla, Asha Rani, Andrew J. Kennedy, Ignazio Piras, Jeremy J. Day, Ashley Siniard, Ashok Kumar, J. David Sweatt, Carol A. Barnes, Matthew J. Huentelman, Thomas C. Foster
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Aging Neuroscience
Subjects:
aging
hippocampus
cognitive function
transcription
gene expression
Illumina HiSeq
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2017.00383/full

Internet

http://journal.frontiersin.org/article/10.3389/fnagi.2017.00383/full

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