Increased Drp1-Mediated Mitochondrial Fission Promotes Proliferation and Collagen Production by Right Ventricular Fibroblasts in Experimental Pulmonary Arterial Hypertension

Increased Drp1-Mediated Mitochondrial Fission Promotes Proliferation and Collagen Production by Right Ventricular Fibroblasts in Experimental Pulmonary Arterial Hypertension

Introduction: Right ventricular (RV) fibrosis contributes to RV failure in pulmonary arterial hypertension (PAH). The mechanisms underlying RV fibrosis in PAH and the role of RV fibroblasts (RVfib) are unknown. Activation of the mitochondrial fission mediator dynamin-related protein 1 (Drp1) contrib...

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Bibliographic Details
Main Authors: Lian Tian, Francois Potus, Danchen Wu, Asish Dasgupta, Kuang-Hueih Chen, Jeffrey Mewburn, Patricia Lima, Stephen L. Archer
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Physiology
Subjects:
mitochondrial fission
mitochondrial dynamics
dynamin-related protein 1 (Drp1)
fibrosis
mitochondrial division inhibitor 1 (Mdivi-1)
P110
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00828/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.00828/full

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