A Threshold Model for T-Cell Activation in the Era of Checkpoint Blockade Immunotherapy

A Threshold Model for T-Cell Activation in the Era of Checkpoint Blockade Immunotherapy

Continued discoveries of negative regulators of inflammatory signaling provide detailed molecular insights into peripheral tolerance and anti-tumor immunity. Accumulating evidence indicates that peripheral tolerance is maintained at multiple levels of immune responses by negative regulators of proin...

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Bibliographic Details
Main Authors: Kripa Guram, Sangwoo S. Kim, Victoria Wu, P. Dominick Sanders, Sandip Patel, Stephen P. Schoenberger, Ezra E. W. Cohen, Si-Yi Chen, Andrew B. Sharabi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
negative regulator
antigen presentation attenuator
threshold model
checkpoint blockade
immunotherapy
PD-1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00491/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00491/full

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