Inhibition of bacterial and human zinc-metalloproteases by bisphosphonate- and catechol-containing compounds

Inhibition of bacterial and human zinc-metalloproteases by bisphosphonate- and catechol-containing compounds

Compounds containg catechol or bisphosphonate were tested as inhibitors of the zinc metalloproteases, thermolysin (TLN), pseudolysin (PLN) and aureolysin (ALN) which are bacterial virulence factors, and the human matrix metalloproteases MMP-9 and −14. Inhibition of virulence is a putative strategy i...

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Bibliographic Details
Main Authors: Fatema Rahman, Tra-Mi Nguyen, Olayiwola A Adekoya, Cristina Campestre, Paolo Tortorella, Ingebrigt Sylte, Jan-Olof Winberg
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
zinc proteases
bacterial virulence factors
matrix metalloproteases
enzyme inhibition
docking and scoring
Online Access:http://dx.doi.org/10.1080/14756366.2021.1901088

Internet

http://dx.doi.org/10.1080/14756366.2021.1901088

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