Development of squaraine based G-quadruplex ligands using click chemistry

Abstract The G-quadruplex (G4) structures of nucleic acids are considered to play an intrinsic role in gene expression. To this end, the development of new G4 ligands has attracted extensive research interests towards potential applications as G4-targeted drugs and molecular probes. To date, the maj...

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Bibliographic Details
Main Authors: Xin Zhang, Yongbiao Wei, Tao Bing, Xiangjun Liu, Nan Zhang, Junyan Wang, Junqing He, Bing Jin, Dihua Shangguan
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-04344-x