Targeting Inflammatory Processes Mediated by TRPVI and TNF-α for Treating Noise-Induced Hearing Loss

Targeting Inflammatory Processes Mediated by TRPVI and TNF-α for Treating Noise-Induced Hearing Loss

Noise trauma is the most common cause of hearing loss in adults. There are no known FDA approved drugs for prevention or rescue of noise-induced hearing loss (NIHL). In this study, we provide evidence that implicates stress signaling molecules (TRPV1, NOX3, and TNF-α) in NIHL. Furthermore, we provid...

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Bibliographic Details
Main Authors: Asmita Dhukhwa, Puspanjali Bhatta, Sandeep Sheth, Krishi Korrapati, Coral Tieu, Chaitanya Mamillapalli, Vickram Ramkumar, Debashree Mukherjea
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
noise exposure
inflammation
TRPV1
TNF-α
capsaicin
Etanercept
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00444/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00444/full

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