Cellular census of human fibrosis defines functionally distinct stromal cell types and states

Cellular census of human fibrosis defines functionally distinct stromal cell types and states

New anti-fibrotics aided by a better understanding of fibrotic cell subsets and their functions are needed. Here the authors perform single-cell RNA-seq and CyTOF on nodules from patients with Dupuytren’s disease to map subsets and the state of mesenchymal cells during pathogenic fibrogenesis.

Bibliographic Details
Main Authors: Thomas B. Layton, Lynn Williams, Fiona McCann, Mingjun Zhang, Marco Fritzsche, Huw Colin-York, Marisa Cabrita, Michael T. H. Ng, Marc Feldmann, Stephen N. Sansom, Dominic Furniss, Weilin Xie, Jagdeep Nanchahal
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16264-y

Internet

https://doi.org/10.1038/s41467-020-16264-y

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