Dysregulated PDGFR alpha expression and novel somatic mutations in colorectal cancer: association to RAS wild type status and tumor size

Dysregulated PDGFR alpha expression and novel somatic mutations in colorectal cancer: association to RAS wild type status and tumor size

Abstract Background Platelet derived growth factor receptor alpha (PDGFRα) has been considered as a relevant factor in tumor proliferation, angiogenesis and metastatic dissemination. It was a target of tyrosine kinase (TK) inhibitors emerged in the therapy of diverse cancers. In colorectal cancer, t...

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Bibliographic Details
Main Authors: Nadia Ben Jemii, Haifa Tounsi-Kettiti, Hamza Yaiche, Najla Mezghanni, Amira Jaballah Gabteni, Emna Fehri, Chayma Ben Fayala, Sonia Abdelhak, Samir Boubaker
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Translational Medicine
Subjects:
Platelet derived growth factor receptor alpha
Colorectal cancer
RAS status
Mutations exon 18
Immunohistochemistry
Online Access:http://link.springer.com/article/10.1186/s12967-020-02614-3

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http://link.springer.com/article/10.1186/s12967-020-02614-3

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