Utrophin influences mitochondrial pathology and oxidative stress in dystrophic muscle

Utrophin influences mitochondrial pathology and oxidative stress in dystrophic muscle

Abstract Background Duchenne muscular dystrophy (DMD) is a lethal X-linked muscle wasting disorder caused by the absence of dystrophin, a large cytoskeletal muscle protein. Increasing the levels of the dystrophin-related-protein utrophin is a highly promising therapy for DMD and has been shown to im...

Full description

Bibliographic Details
Main Authors: Tahnee L. Kennedy, Lee Moir, Sarah Hemming, Ben Edwards, Sarah Squire, Kay Davies, Simon Guiraud
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Skeletal Muscle
Subjects:
Duchenne muscular dystrophy
Mitochondria defects
Oxidative stress
Utrophin
Online Access:http://link.springer.com/article/10.1186/s13395-017-0139-5

Internet

http://link.springer.com/article/10.1186/s13395-017-0139-5

Similar Items