Discovery of Drug Synergies in Gastric Cancer Cells Predicted by Logical Modeling.

Discovery of efficient anti-cancer drug combinations is a major challenge, since experimental testing of all possible combinations is clearly impossible. Recent efforts to computationally predict drug combination responses retain this experimental search space, as model definitions typically rely on...

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Bibliographic Details
Main Authors: Åsmund Flobak, Anaïs Baudot, Elisabeth Remy, Liv Thommesen, Denis Thieffry, Martin Kuiper, Astrid Lægreid
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-08-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1004426