The Use of CRISPR/Cas9 Gene Editing to Confirm Congenic Contaminations in Host-Pathogen Interaction Studies

The Use of CRISPR/Cas9 Gene Editing to Confirm Congenic Contaminations in Host-Pathogen Interaction Studies

Murine models of Salmonella enterica serovar Typhimurium infection are one of the commonest tools to study host-pathogen interactions during bacterial infections. Critically, the outcome of S. Typhimurium infection is impacted by the genetic background of the mouse strain used, with macrophages from...

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Bibliographic Details
Main Authors: Jonathan Ferrand, Nathan P. Croft, Geneviève Pépin, Kerrilyn R. Diener, Di Wu, Niamh E. Mangan, John Pedersen, Mark A. Behlke, John D. Hayball, Anthony W. Purcell, Richard L. Ferrero, Michael P. Gantier
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Salmonella
CRISPR/CAS9
congenic mice
background contamination
host-pathogen interactions
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2018.00087/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2018.00087/full

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