Depletion of DNMT1 in differentiated human cells highlights key classes of sensitive genes and an interplay with polycomb repression

Depletion of DNMT1 in differentiated human cells highlights key classes of sensitive genes and an interplay with polycomb repression

Abstract Background DNA methylation plays a vital role in the cell, but loss-of-function mutations of the maintenance methyltransferase DNMT1 in normal human cells are lethal, precluding target identification, and existing hypomorphic lines are tumour cells. We generated instead a hypomorphic series...

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Bibliographic Details
Main Authors: Karla M. O’Neill, Rachelle E. Irwin, Sarah-Jayne Mackin, Sara-Jayne Thursby, Avinash Thakur, Ciske Bertens, Laura Masala, Jayne E. P. Loughery, Darragh G. McArt, Colum P. Walsh
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Epigenetics & Chromatin
Subjects:
DNMT1
EZH2
Protocadherin
Body mass
Cancer/testis antigen
Online Access:http://link.springer.com/article/10.1186/s13072-018-0182-4

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http://link.springer.com/article/10.1186/s13072-018-0182-4

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