Impaired Nuclear Export of the Ribonucleoprotein Complex and Virus-Induced Cytotoxicity Combine to Restrict Propagation of the A/Duck/Malaysia/02/2001 (H9N2) Virus in Human Airway Cells

Impaired Nuclear Export of the Ribonucleoprotein Complex and Virus-Induced Cytotoxicity Combine to Restrict Propagation of the A/Duck/Malaysia/02/2001 (H9N2) Virus in Human Airway Cells

In humans, (A549) cells impaired H9N2 virus nuclear export of the ribonucleoprotein (RNP) complex contrasted with the early and efficient nuclear export of the H1N1/WSN and pH1N1 virus RNP complexes. Although nuclear export of the RNP complex occurred via the nuclear pore complex, H9N2 virus infecti...

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Bibliographic Details
Main Authors: Sriram Kumar, Dawn Yeo, Nisha Harur Muralidharan, Soak Kuan Lai, Cathlyn Tong, Boon Huan Tan, Richard J. Sugrue
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
avian influenza virus
h9n2 virus
nucleoprotein
ribonucleoprotein (rnp) complex
pa protein
lamin a/c
Online Access:https://www.mdpi.com/2073-4409/9/2/355

Internet

https://www.mdpi.com/2073-4409/9/2/355

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