Preferential Coupling of Dopamine D<sub>2S</sub> and D<sub>2L</sub> Receptor Isoforms with G<sub>i1</sub> and G<sub>i2</sub> Proteins—In Silico Study

Preferential Coupling of Dopamine D<sub>2S</sub> and D<sub>2L</sub> Receptor Isoforms with G<sub>i1</sub> and G<sub>i2</sub> Proteins—In Silico Study

The dopamine D<sub>2</sub> receptor belongs to rhodopsin-like G protein-coupled receptors (GPCRs) and it is an important molecular target for the treatment of many disorders, including schizophrenia and Parkinson&#8217;s disease. Here, computational methods were used to construct the...

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Bibliographic Details
Main Authors: Justyna Żuk, Damian Bartuzi, Dariusz Matosiuk, Agnieszka A. Kaczor
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
dopamine d<sub>2</sub> receptor
gpcrs
molecular dynamics
molecular switches
principal component analysis
Online Access:https://www.mdpi.com/1422-0067/21/2/436

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https://www.mdpi.com/1422-0067/21/2/436

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