Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts

Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts

Larval tracheae of Drosophila harbour progenitors of the adult tracheal system (tracheoblasts). Thoracic tracheoblasts are arrested in the G2 phase of the cell cycle in an ATR (mei-41)-Checkpoint Kinase1 (grapes, Chk1) dependent manner prior to mitotic re-entry. Here we investigate developmental reg...

Full description

Bibliographic Details
Main Authors: Amrutha Kizhedathu, Rose Sebastian Kunnappallil, Archit V Bagul, Puja Verma, Arjun Guha
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
tracheoblasts
Wnt
G2 arrest
Checkpoint Kinase I
Online Access:https://elifesciences.org/articles/57056

Internet

https://elifesciences.org/articles/57056

Similar Items