Identification of FDA-approved antivirulence drugs targeting the Pseudomonas aeruginosa quorum sensing effector protein PqsE

Identification of FDA-approved antivirulence drugs targeting the Pseudomonas aeruginosa quorum sensing effector protein PqsE

The ability of the bacterial pathogen Pseudomonas aeruginosa to cause both chronic and acute infections mainly relies on its capacity to finely modulate the expression of virulence factors through a complex network of regulatory circuits, including the pqs quorum sensing (QS) system. While in most Q...

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Bibliographic Details
Main Authors: Valerio Baldelli, Francesca D’Angelo, Viola Pavoncello, Ersilia Vita Fiscarelli, Paolo Visca, Giordano Rampioni, Livia Leoni
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Virulence
Subjects:
pseudomonas aeruginosa
antivirulence strategy
quorum sensing inhibition
nitrofurazone
erythromycin estolate
screening
pqse
Online Access:http://dx.doi.org/10.1080/21505594.2020.1770508

Internet

http://dx.doi.org/10.1080/21505594.2020.1770508

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