Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation

Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation

Parkinson's disease (PD) affects motor function through degenerative processes and synaptic transmission impairments in the basal ganglia. None of the treatments available delays or stops the progression of the disease. While α-synuclein pathological accumulation represents a hallmark of the di...

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Bibliographic Details
Main Authors: Michael Aagaard Andersen, Kenneth Vielsted Christensen, Lassina Badolo, Garrick Paul Smith, Ross Jeggo, Poul Henning Jensen, Kathrine Just Andersen, Florence Sotty
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:Neurobiology of Disease
Subjects:
PFE-360
LRRK2 inhibition
LRRK2 inhibitor
Parkinson's disease
AAV-alpha-synuclein
In vivo electrophysiology
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118301190

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http://www.sciencedirect.com/science/article/pii/S0969996118301190

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