Conformations and cryo-force spectroscopy of spray-deposited single-strand DNA on gold

Conformations and cryo-force spectroscopy of spray-deposited single-strand DNA on gold

Cryo-electron microscopy can determine the structure but not the nanomechanics of biological matter. Here the authors combine force spectroscopy in cryogenic conditions with computer simulations to characterize the properties of DNA simultaneously down to the sub-nm level.

Bibliographic Details
Main Authors: Rémy Pawlak, J. G. Vilhena, Antoine Hinaut, Tobias Meier, Thilo Glatzel, Alexis Baratoff, Enrico Gnecco, Rubén Pérez, Ernst Meyer
Format: Article
Language:English
Published: Nature Publishing Group 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08531-4
Description
Summary:Cryo-electron microscopy can determine the structure but not the nanomechanics of biological matter. Here the authors combine force spectroscopy in cryogenic conditions with computer simulations to characterize the properties of DNA simultaneously down to the sub-nm level.
ISSN:2041-1723

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