MicroRNA-181a as novel liquid biopsy marker of central nervous system involvement in pediatric acute lymphoblastic leukemia

MicroRNA-181a as novel liquid biopsy marker of central nervous system involvement in pediatric acute lymphoblastic leukemia

Abstract Background Refractory central nervous system (CNS) involvement is among the major causes of therapy failure in childhood acute leukemia. Applying contemporary diagnostic methods, CNS disease is often underdiagnosed. To explore more sensitive and less invasive CNS status indicators, we exami...

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Bibliographic Details
Main Authors: Bálint Egyed, Nóra Kutszegi, Judit C. Sági, András Gézsi, Andrea Rzepiel, Tamás Visnovitz, Péter Lőrincz, Judit Müller, Marianna Zombori, Csaba Szalai, Dániel J. Erdélyi, Gábor T. Kovács, Ágnes F. Semsei
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Translational Medicine
Subjects:
Central nervous system involvement
Pediatric leukemia
Liquid biopsy
microRNA-based biomarker
Small extracellular vesicles
Online Access:http://link.springer.com/article/10.1186/s12967-020-02415-8

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http://link.springer.com/article/10.1186/s12967-020-02415-8

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