Magnolol Prevents Acute Alcoholic Liver Damage by Activating PI3K/Nrf2/PPARγ and Inhibiting NLRP3 Signaling Pathway

Magnolol Prevents Acute Alcoholic Liver Damage by Activating PI3K/Nrf2/PPARγ and Inhibiting NLRP3 Signaling Pathway

Alcoholic liver damage (ALD) is a toxic liver damage caused by excessive drinking. Oxidative stress is one of the most crucial pathogenic factors leading to ALD. Magnolol is one of the main active constituents of traditional Chinese medicine Magnolia officinalis, which has been reported to possess m...

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Bibliographic Details
Main Authors: Xiao Liu, Yanan Wang, Di Wu, Shuangqiu Li, Chaoqun Wang, Zhen Han, Jingjing Wang, Kai Wang, Zhengtao Yang, Zhengkai Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Pharmacology
Subjects:
alcoholic liver disease
magnolol
oxidative stress
NLRP3
PPARγ
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01459/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01459/full

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