Mucus Release and Airway Constriction by TMEM16A May Worsen Pathology in Inflammatory Lung Disease

Mucus Release and Airway Constriction by TMEM16A May Worsen Pathology in Inflammatory Lung Disease

Activation of the Ca<sup>2+</sup> activated Cl<sup>−</sup> channel TMEM16A is proposed as a treatment in inflammatory airway disease. It is assumed that activation of TMEM16A will induce electrolyte secretion, and thus reduce airway mucus plugging and improve mucociliary clea...

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Bibliographic Details
Main Authors: Raquel Centeio, Jiraporn Ousingsawat, Inês Cabrita, Rainer Schreiber, Khaoula Talbi, Roberta Benedetto, Tereza Doušová, Eric K. Verbeken, Kris De Boeck, Isaac Cohen, Karl Kunzelmann
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
TMEM16A
ETX001
Eact
brevenal
asthma
cystic fibrosis
Online Access:https://www.mdpi.com/1422-0067/22/15/7852

Internet

https://www.mdpi.com/1422-0067/22/15/7852

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