Identification of PHRF1 as a Tumor Suppressor that Promotes the TGF-β Cytostatic Program through Selective Release of TGIF-Driven PML Inactivation

Identification of PHRF1 as a Tumor Suppressor that Promotes the TGF-β Cytostatic Program through Selective Release of TGIF-Driven PML Inactivation

The homeodomain protein TGIF (TG-interacting factor) restricts TGF-β/Smad cytostatic signaling by interfering with the nucleocytoplasmic transit of the tumor suppressor cPML. Here, we identify PHRF1 as a ubiquitin ligase that enforces TGIF decay by driving its ubiquitination at lysine 130. In so do...

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Bibliographic Details
Main Authors: Asma Ettahar, Olivier Ferrigno, Ming-Zhu Zhang, Mutsuko Ohnishi, Nathalie Ferrand, Céline Prunier, Laurence Levy, Marie-Françoise Bourgeade, Ivan Bieche, Damian G. Romero, Frédéric Colland, Azeddine Atfi
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713003562

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http://www.sciencedirect.com/science/article/pii/S2211124713003562

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