Identification of New Rofecoxib-Based Cyclooxygenase-2 Inhibitors: A Bioinformatics Approach

Identification of New Rofecoxib-Based Cyclooxygenase-2 Inhibitors: A Bioinformatics Approach

The cyclooxygenase-2 receptor is a therapeutic target for planning potential drugs with anti-inflammatory activity. The selective cyclooxygenase-2 (COX-2) inhibitor rofecoxib was selected as a pivot molecule to perform virtual ligand-based screening from six commercial databases. We performed the se...

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Bibliographic Details
Main Authors: Rozires P. Leão, Josiane V. Cruz, Glauber V. da Costa, Jorddy N. Cruz, Elenilze F. B. Ferreira, Raí C. Silva, Lúcio R. de Lima, Rosivaldo S. Borges, Gabriela B. dos Santos, Cleydson B. R. Santos
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Pharmaceuticals
Subjects:
anti-inflammatory
cyclooxygenase-2
rofecoxib
bioinformatics
Online Access:https://www.mdpi.com/1424-8247/13/9/209

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https://www.mdpi.com/1424-8247/13/9/209

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