From Toxicity to Selectivity: Coculture of the Fluorescent Tumor and Non-Tumor Lung Cells and High-Throughput Screening of Anticancer Compounds

From Toxicity to Selectivity: Coculture of the Fluorescent Tumor and Non-Tumor Lung Cells and High-Throughput Screening of Anticancer Compounds

For the search of anticancer compounds in modern large chemical libraries, new approaches are of great importance. Cocultivation of the cells of tumor and non-tumor etiology may reveal specific action of chemicals on cancer cells and also take into account some effects of the tumor cell’s microenvir...

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Bibliographic Details
Main Authors: D.A. Skvortsov, M.A. Kalinina, I.V. Zhirkina, L.A. Vasilyeva, Y.A. Ivanenkov, P.V. Sergiev, O.A. Dontsova
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Pharmacology
Subjects:
phenotypic screening
anticancer compounds
cytotoxicity
high-throughput
fluorescence detection
lung cancer model
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.713103/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.713103/full

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