Chitosan Hydrogel Doped with PEG-PLA Nanoparticles for the Local Delivery of miRNA-146a to Treat Allergic Rhinitis

Chitosan Hydrogel Doped with PEG-PLA Nanoparticles for the Local Delivery of miRNA-146a to Treat Allergic Rhinitis

To prepare a binary formulation delivering miRNA-146 and evaluate a nucleic acid nasal delivery system by investigating its pharmacodynamic effects in allergic rhinitis. The gel/NPs/miR-146a thermosensitive in situ chitosan hydrogel carrying a nucleic acid was prepared and evaluated for its characte...

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Bibliographic Details
Main Authors: Yu Su, Bixi Sun, Xiaoshu Gao, Shuwen Liu, Rubin Hao, Bing Han
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Pharmaceutics
Subjects:
nanoparticles
binary formulation
allergic rhinitis
miR-146a
Online Access:https://www.mdpi.com/1999-4923/12/10/907

Internet

https://www.mdpi.com/1999-4923/12/10/907

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