V(D)J Rearrangement Is Dispensable for Producing CDR-H3 Sequence Diversity in a Gene Converting Species

V(D)J Rearrangement Is Dispensable for Producing CDR-H3 Sequence Diversity in a Gene Converting Species

An important characteristic of chickens is that the antibody repertoire is based on a single framework, with diversity found mainly in the CDRs of the light and heavy chain variable regions. Despite this apparent limitation in the antibody repertoire, high-affinity antibodies can be raised to a wide...

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Bibliographic Details
Main Authors: Philip A. Leighton, Jacqueline Morales, William D. Harriman, Kathryn H. Ching
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
CDR-H3 repertoire
somatic hypermutation
transgenic chickens
gene conversion
V(D)J rearrangement
human monoclonal antibodies
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01317/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01317/full

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