V(D)J Rearrangement Is Dispensable for Producing CDR-H3 Sequence Diversity in a Gene Converting Species

by Philip A. Leighton, Jacqueline Morales, William D. Harriman, Kathryn H. Ching
Published 2018-06-01

A diverse repertoire of human immunoglobulin variable genes in a chicken B cell line is generated by both gene conversion and somatic hypermutation

by Philip A. Leighton, Benjamin eSchusser, Henry eYi, Jacob eGlanville, William eHarriman
Published 2015-03-01

Expression of human lambda expands the repertoire of OmniChickens.

by Kathryn H Ching, Kimberley Berg, Jacqueline Morales, Darlene Pedersen, William D Harriman, Yasmina N Abdiche, Philip A Leighton
Published 2020-01-01

Harnessing gene conversion in chicken B cells to create a human antibody sequence repertoire.

by Benjamin Schusser, Henry Yi, Ellen J Collarini, Shelley Mettler Izquierdo, William D Harriman, Robert J Etches, Philip A Leighton
Published 2013-01-01

Germline Gene Editing in Chickens by Efficient CRISPR-Mediated Homologous Recombination in Primordial Germ Cells.

by Lazar Dimitrov, Darlene Pedersen, Kathryn H Ching, Henry Yi, Ellen J Collarini, Shelley Izquierdo, Marie-Cecile van de Lavoir, Philip A Leighton
Published 2016-01-01

Interspecific germline transmission of cultured primordial germ cells.

by Marie-Cecile van de Lavoir, Ellen J Collarini, Philip A Leighton, Jeffrey Fesler, Daniel R Lu, William D Harriman, T S Thiyagasundaram, Robert J Etches
Published 2012-01-01

Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms.

by Beatrice Cameron, Tarik Dabdoubi, Laurence Berthou-Soulié, Marie Gagnaire, Isabelle Arnould, Anne Severac, Fabienne Soubrier, Jacqueline Morales, Philip A Leighton, William Harriman, Kathryn Ching, Yasmina Abdiche, Katarina Radošević, Thomas Bouquin
Published 2020-01-01