High spatial resolution nanoslit SERS for single-molecule nucleobase sensing

High spatial resolution nanoslit SERS for single-molecule nucleobase sensing

Direct and real-time identification of nucleobases in DNA strands is still limited by the sensitivity and spatial resolution of the established solid-state nanopore devices. Here, the authors use CMOS compatible, plasmonic nanoslits to locally enable SERS for identifying nucleobases, both individual...

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Main Authors: Chang Chen, Yi Li, Sarp Kerman, Pieter Neutens, Kherim Willems, Sven Cornelissen, Liesbet Lagae, Tim Stakenborg, Pol Van Dorpe
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04118-7
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spelling doaj-7db9e4ba038b4686a141eb151a1419962021-05-11T09:37:06ZengNature Publishing GroupNature Communications2041-17232018-04-01911910.1038/s41467-018-04118-7High spatial resolution nanoslit SERS for single-molecule nucleobase sensingChang Chen0Yi Li1Sarp Kerman2Pieter Neutens3Kherim Willems4Sven Cornelissen5Liesbet Lagae6Tim Stakenborg7Pol Van Dorpe8imecimecimecimecimecimecimecimecimecDirect and real-time identification of nucleobases in DNA strands is still limited by the sensitivity and spatial resolution of the established solid-state nanopore devices. Here, the authors use CMOS compatible, plasmonic nanoslits to locally enable SERS for identifying nucleobases, both individual and incorporated in DNA strands.https://doi.org/10.1038/s41467-018-04118-7
collection DOAJ
language English
format Article
sources DOAJ
author Chang Chen
Yi Li
Sarp Kerman
Pieter Neutens
Kherim Willems
Sven Cornelissen
Liesbet Lagae
Tim Stakenborg
Pol Van Dorpe
spellingShingle Chang Chen
Yi Li
Sarp Kerman
Pieter Neutens
Kherim Willems
Sven Cornelissen
Liesbet Lagae
Tim Stakenborg
Pol Van Dorpe
High spatial resolution nanoslit SERS for single-molecule nucleobase sensing
Nature Communications
author_facet Chang Chen
Yi Li
Sarp Kerman
Pieter Neutens
Kherim Willems
Sven Cornelissen
Liesbet Lagae
Tim Stakenborg
Pol Van Dorpe
author_sort Chang Chen
title High spatial resolution nanoslit SERS for single-molecule nucleobase sensing
title_short High spatial resolution nanoslit SERS for single-molecule nucleobase sensing
title_full High spatial resolution nanoslit SERS for single-molecule nucleobase sensing
title_fullStr High spatial resolution nanoslit SERS for single-molecule nucleobase sensing
title_full_unstemmed High spatial resolution nanoslit SERS for single-molecule nucleobase sensing
title_sort high spatial resolution nanoslit sers for single-molecule nucleobase sensing
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-04-01
description Direct and real-time identification of nucleobases in DNA strands is still limited by the sensitivity and spatial resolution of the established solid-state nanopore devices. Here, the authors use CMOS compatible, plasmonic nanoslits to locally enable SERS for identifying nucleobases, both individual and incorporated in DNA strands.
url https://doi.org/10.1038/s41467-018-04118-7
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AT sarpkerman highspatialresolutionnanoslitsersforsinglemoleculenucleobasesensing
AT pieterneutens highspatialresolutionnanoslitsersforsinglemoleculenucleobasesensing
AT kherimwillems highspatialresolutionnanoslitsersforsinglemoleculenucleobasesensing
AT svencornelissen highspatialresolutionnanoslitsersforsinglemoleculenucleobasesensing
AT liesbetlagae highspatialresolutionnanoslitsersforsinglemoleculenucleobasesensing
AT timstakenborg highspatialresolutionnanoslitsersforsinglemoleculenucleobasesensing
AT polvandorpe highspatialresolutionnanoslitsersforsinglemoleculenucleobasesensing
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