Telomeres and Telomere Length: A General Overview

Telomeres and Telomere Length: A General Overview

Telomeres are highly conserved tandem nucleotide repeats that include proximal double-stranded and distal single-stranded regions that in complex with shelterin proteins afford protection at chromosomal ends to maintain genomic integrity. Due to the inherent limitations of DNA replication and telome...

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Bibliographic Details
Main Authors: Nalini Srinivas, Sivaramakrishna Rachakonda, Rajiv Kumar
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
telomeres
shelterin complex
end replication
telomere maintenance mechanisms
tert promoter mutations
telomere length heritability
genetic variants
cancer-risk
Online Access:https://www.mdpi.com/2072-6694/12/3/558

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https://www.mdpi.com/2072-6694/12/3/558

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